Microtubule dynamics and tubulin interacting proteins

Curr Opin Cell Biol. 2000 Feb;12(1):52-6. doi: 10.1016/s0955-0674(99)00056-3.


Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op 18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.

Publication types

  • Review

MeSH terms

  • Animals
  • Dimerization
  • Kinesins / metabolism*
  • Microtubule Proteins*
  • Microtubules / metabolism*
  • Phosphoproteins / metabolism*
  • Stathmin
  • Tubulin / metabolism*
  • Xenopus Proteins*


  • KIF11 protein, Xenopus
  • Microtubule Proteins
  • Phosphoproteins
  • Stathmin
  • Tubulin
  • Xenopus Proteins
  • Kinesins