New Approaches for Cell-Specific Targeting: Identification of Cell-Selective Peptides From Combinatorial Libraries

Curr Opin Chem Biol. 2000 Feb;4(1):16-21. doi: 10.1016/s1367-5931(99)00045-9.

Abstract

Peptides that recognize specific cell types promise to be valuable tools both in research and clinical applications. Cell-specific peptides can be useful as drug delivery vehicles, diagnostic agents, affinity reagents for cell purification, gene therapy delivery agents, and research tools to probe the nature of a cell's surface. Recently, cell-specific targeting-peptides have been identified by phage-display selections against purified cell-surface markers, whole cells in tissue culture, and even tissues within live animals. These methods for identifying cell-targeting peptides will certainly increase the tools available to the scientist for cell-specific targeting.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteriophages / genetics
  • Combinatorial Chemistry Techniques*
  • Organ Specificity
  • Peptide Library*
  • Receptors, Cell Surface / chemistry

Substances

  • Peptide Library
  • Receptors, Cell Surface