Abstract
The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ADP-Ribosylation Factors / physiology*
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Animals
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Carrier Proteins / physiology
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Cyclin-Dependent Kinase Inhibitor p16
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Cyclin-Dependent Kinases / antagonists & inhibitors
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Genes, Tumor Suppressor*
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Humans
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Mice
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Nuclear Proteins*
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Oncogenes
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Proto-Oncogene Proteins / physiology
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Proto-Oncogene Proteins c-mdm2
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Tumor Suppressor Protein p53 / physiology*
Substances
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Carrier Proteins
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Cyclin-Dependent Kinase Inhibitor p16
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Nuclear Proteins
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Proto-Oncogene Proteins
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Tumor Suppressor Protein p53
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MDM2 protein, human
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Mdm2 protein, mouse
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Proto-Oncogene Proteins c-mdm2
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Cyclin-Dependent Kinases
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ADP-Ribosylation Factors