The ARF/p53 pathway

Curr Opin Genet Dev. 2000 Feb;10(1):94-9. doi: 10.1016/s0959-437x(99)00038-6.


The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADP-Ribosylation Factors / physiology*
  • Animals
  • Carrier Proteins / physiology
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclin-Dependent Kinases / antagonists & inhibitors
  • Genes, Tumor Suppressor*
  • Humans
  • Mice
  • Nuclear Proteins*
  • Oncogenes
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-mdm2
  • Tumor Suppressor Protein p53 / physiology*


  • Carrier Proteins
  • Cyclin-Dependent Kinase Inhibitor p16
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • MDM2 protein, human
  • Mdm2 protein, mouse
  • Proto-Oncogene Proteins c-mdm2
  • Cyclin-Dependent Kinases
  • ADP-Ribosylation Factors