Controlling the end of the cell cycle

Curr Opin Genet Dev. 2000 Feb;10(1):65-9. doi: 10.1016/s0959-437x(99)00044-1.


The past year has seen significant advances in our understanding of how the events which occur at the end of mitosis, such as cytokinesis and the inactivation of mitotic cyclin dependent kinases are triggered, and also how they are prevented from occurring prematurely or inappropriately. This control is achieved through a combination of temporally ordered proteolytic events and changes in the subcellular localisation of proteins. These studies have also revealed that the nucleolus and spindle pole bodies play a key role in this regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Genes, cdc / physiology*
  • Humans
  • Ligases / metabolism
  • Mitosis / genetics*
  • Mitosis / physiology
  • Ubiquitin-Protein Ligase Complexes*
  • Ubiquitin-Protein Ligases
  • Yeasts


  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • Ubiquitin-Protein Ligases
  • Ligases