NF-kappaB and the innate immune response

Curr Opin Immunol. 2000 Feb;12(1):52-8. doi: 10.1016/s0952-7915(99)00050-3.


In the innate immune reaction, microbial pathogens activate phylogenetically conserved cellular signal transduction pathways that regulate the ubiquitous nuclear factor-kappaB (NFkappaB). NF-kappaB has pleiotropic functions in immunity; however, it is also critical for development and cellular survival. Many aspects of how the different pathways utilize a common kinase complex that ultimately activates NF-kappaB have been clarified by gene inactivation and biochemical analysis.

Publication types

  • Review

MeSH terms

  • Enzyme Activation
  • I-kappa B Kinase
  • Immunity, Innate*
  • NF-kappa B / metabolism*
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction
  • Virulence / immunology


  • NF-kappa B
  • Protein-Serine-Threonine Kinases
  • I-kappa B Kinase