The control of T cell responses by dendritic cell subsets

Curr Opin Immunol. 2000 Feb;12(1):114-21. doi: 10.1016/s0952-7915(99)00059-x.


Dendritic cells are known as the most efficient antigen-presenting cell type to activate naïve T cells; however, they are able to do more than just efficiently present antigen to T cells. They are key modulators of the immune response that can influence Th cell differentiation by preferentially inducing Th type 1 or 2 cell responses, and the differential polarisation of CD4(+) T cells appears to be mediated by discrete dendritic cell subsets.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Antigens, Differentiation, T-Lymphocyte
  • Cytokines / metabolism
  • Dendritic Cells / classification*
  • Humans
  • Mice
  • T-Lymphocytes / immunology*


  • Antigens, Differentiation, T-Lymphocyte
  • Cytokines