Tlr4: central component of the sole mammalian LPS sensor

Curr Opin Immunol. 2000 Feb;12(1):20-6. doi: 10.1016/s0952-7915(99)00046-1.

Abstract

Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.

Publication types

  • Review

MeSH terms

  • Alleles
  • Drosophila Proteins*
  • Genes, Dominant
  • Genes, Recessive
  • Insect Proteins / genetics
  • Lipopolysaccharide Receptors / genetics
  • Lipopolysaccharide Receptors / metabolism*
  • Lipopolysaccharides / immunology*
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / metabolism*
  • Models, Immunological
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Insect Proteins
  • Lipopolysaccharide Receptors
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Tl protein, Drosophila
  • Toll-Like Receptor 2
  • Toll-Like Receptor 4
  • Toll-Like Receptors