Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesis

Curr Opin Microbiol. 2000 Feb;3(1):29-34. doi: 10.1016/s1369-5274(99)00047-8.


In the past year, a Caenorhabditis elegans-Pseudomonas aeruginosa pathogenesis model has been developed to facilitate the systematic dissection of both host and pathogen genes involved in pathogenic interactions. Analysis of the P. aeruginosa-C. elegans interaction should shed light on the larger question of how organisms interact at the molecular level in antagonistic relationships.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / immunology
  • Caenorhabditis elegans / microbiology*
  • Mice
  • Models, Biological
  • Pseudomonas Infections / immunology
  • Pseudomonas Infections / physiopathology
  • Pseudomonas aeruginosa / genetics*
  • Pseudomonas aeruginosa / pathogenicity*
  • Virulence