Bacterial pili: molecular mechanisms of pathogenesis

Curr Opin Microbiol. 2000 Feb;3(1):65-72. doi: 10.1016/s1369-5274(99)00053-3.

Abstract

Gram-negative bacteria produce a diverse array of pili that mediate microbe-microbe and host-pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the host upon attachment, has begun to reveal the molecular mechanisms of bacterial diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacterial Adhesion
  • Bacterial Proteins / metabolism
  • Cytokines / metabolism
  • Escherichia coli / metabolism
  • Escherichia coli / pathogenicity*
  • Escherichia coli / ultrastructure
  • Escherichia coli Infections / metabolism
  • Escherichia coli Infections / microbiology*
  • Escherichia coli Infections / pathology
  • Fimbriae, Bacterial / genetics
  • Fimbriae, Bacterial / metabolism*
  • Humans
  • Molecular Chaperones / metabolism
  • Urinary Tract Infections / metabolism
  • Urinary Tract Infections / microbiology*
  • Urinary Tract Infections / pathology

Substances

  • Bacterial Proteins
  • Cytokines
  • Molecular Chaperones