Active killing of neurons during development and following stress: a role for p75(NTR) and Fas?

Curr Opin Neurobiol. 2000 Feb;10(1):111-7. doi: 10.1016/s0959-4388(99)00055-0.

Abstract

Evidence for active triggering of neuronal death continues to accumulate. The transmembrane receptors p75(NTR) and Fas can trigger (and in some cases are required for) programmed cell death of the neurons that express them, through signalling pathways that are regulated by a variety of cytoplasmic effectors. Neuronal death induced by trophic deprivation often requires Fas signalling, further blurring the boundaries between naturally occurring and stress-induced neuronal death.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Fas Ligand Protein
  • Humans
  • Membrane Glycoproteins / metabolism
  • Nervous System / cytology
  • Nervous System / embryology
  • Nervous System / growth & development*
  • Nervous System / physiopathology
  • Neurons / cytology*
  • Neurons / metabolism
  • Receptors, Nerve Growth Factor / chemistry
  • Receptors, Nerve Growth Factor / metabolism*
  • Signal Transduction
  • Stress, Physiological / pathology
  • Stress, Physiological / physiopathology*
  • Up-Regulation
  • fas Receptor / metabolism*

Substances

  • FASLG protein, human
  • Fas Ligand Protein
  • Membrane Glycoproteins
  • Receptors, Nerve Growth Factor
  • fas Receptor