From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility

Curr Opin Neurobiol. 2000 Feb;10(1):80-7. doi: 10.1016/s0959-4388(99)00058-6.


The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Actins / metabolism*
  • Animals
  • Cell Adhesion
  • Cell Adhesion Molecules / metabolism
  • Cell Movement
  • Cytoskeleton / metabolism
  • Drosophila Proteins
  • Growth Cones / enzymology*
  • Growth Cones / physiology*
  • Phosphorylation
  • Protein Binding
  • Protein Tyrosine Phosphatases / metabolism
  • Proto-Oncogene Proteins c-abl / metabolism*
  • Receptor-Like Protein Tyrosine Phosphatases
  • rho GTP-Binding Proteins / metabolism


  • Actins
  • Cell Adhesion Molecules
  • Drosophila Proteins
  • Proto-Oncogene Proteins c-abl
  • Lar protein, Drosophila
  • Protein Tyrosine Phosphatases
  • Receptor-Like Protein Tyrosine Phosphatases
  • rho GTP-Binding Proteins