Abstract
Recent biochemical and structural studies have shown that the preferential recognition of distorted DNA structures, including DNA bulges, four-way junctions and cis-platinated DNA, by HMG domains is dependent on residues immediately preceding the second alpha helix of the L-shaped HMG domain.
MeSH terms
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Amino Acid Sequence
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DNA Damage*
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DNA Repair
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High Mobility Group Proteins / chemistry
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High Mobility Group Proteins / metabolism*
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Macromolecular Substances
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Models, Molecular
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Molecular Sequence Data
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Nucleic Acid Conformation*
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Protein Binding
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Protein Structure, Tertiary
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Sequence Alignment
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Sequence Homology, Nucleic Acid
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Substrate Specificity
Substances
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High Mobility Group Proteins
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Macromolecular Substances