Objective: This study was aimed at determining the physical and biological properties of fibroin membrane and evaluating its clinical effects.
Methods: 1. The physical and biological properties of fibroin membrane and partial thickness porcine skin were determined with various instruments. The determinations included water ratio, tensile strength, flexibility, water permeability, adhesive force and so on. 2.
Clinical observation: Two wounds with same depth in the same patient were selected. One was covered by fibroin membrane. The other one was treated with 1% SD-Ag cream. The changes in these wounds were observed and compared.
Results: This membrane had nearly same physical and biological properties compared with partial thickness porcine skin. It had no toxicity, irritation, and antigenicity. It possessed certain amount of water permeability and could adhere to the wound. Because of its good transparency, any change in underlying wound could be directly observed. It was helpful not only in local therapy but also in study of wound healing. CLINICAL OBSERVATIONs showed that this membrane had good protecting effect to wound. Its application could obviously relieve pain of wound and the healing time was 3-5 days ahead than that of the control wound.
Conclusion: This membrane was an ideal wound covering and was worth being popularized.