Nonclassical effects of 1alpha,25-dihydroxyvitamin D(3) and its analogs

Miner Electrolyte Metab. Jul-Dec 1999;25(4-6):345-8. doi: 10.1159/000057472.


The activated form of vitamin D(3), 1alpha,25(OH)(2)D(3), not only plays a central role in bone and calcium metabolism but has also potent antiproliferative and prodifferentiating effects. Moreover, the combined presence of 25(OH)D(3)-1alpha-hydroxylase as well as the vitamin D receptor in several tissues introduced the idea of a paracrine role for 1alpha,25(OH)(2)D(3). By introducing chemical modifications into the flexible parent molecule 1alpha,25(OH)(2)D(3), a whole generation of vitamin D analogs was created. Due to a clear dissociation of the antiproliferative and prodifferentiating effects from calcemic effects, these analogs can be used not only for the treatment of bone disorders but also for non-classical applications.

Publication types

  • Review

MeSH terms

  • Bone and Bones / drug effects
  • Bone and Bones / metabolism
  • Calcitriol / analogs & derivatives*
  • Calcitriol / pharmacology*
  • Calcitriol / therapeutic use
  • Calcium / blood
  • Cell Differentiation / drug effects
  • Cell Division / drug effects
  • Humans
  • Neoplasms / drug therapy
  • Skin Diseases / drug therapy


  • Calcitriol
  • Calcium