Plasma testosterone(T), estrodiol(E), total cholesterol(TC), triglyceride(TG), high density lipoprotein-cholesterol(HDL-C), HDL2-C, HDL3-C, lipoprotein(a)[Lp(a)], apolipoprotein(Apo) AI and B100 were determined in 201 subjects, among them 102 patients with coronary heart disease(CHD) and 99 healthy subjects. It was observed that plasma T level was correlated negatively with TG(r = -0.47, P < 0.01) and Lp(a) (r = -0.163, P < 0.05), and positively with HDL3-C(r = 0.328, P < 0.01) and Lp(a)(r = -0.163, P < 0.05), and positively with HDL-3(r = 0.328, P < 0.01) and HDL3-C(r = 0.328, P < 0.01). Meanwhile, plasma levels of TG (1.47 +/- 1.16 mmol.L-1) and Lp(a)(25 +/- 17.8 g.L-1) were significantly higher in the subjects with low plasma T level (< 270 ng.ml-1) than those in the subjects with normal plasma T level (1.10 +/- 0.74 mmol.L-1 and 17 +/- 15.9 g.L-1, respectively), while plasma levels of HDL-C (1.31 +/- 0.30 mmol.L-1) and HDL3-C(0.88 +/- 0.22 mmol.L-1) were significantly lower in the former than in the latter (1.44 +/- 0.33 mmol.L-1 and 1.02 +/- 0.26 mmol.L-1, respectively). The results support that low plasma T level may be a risk factor for coronary heart disease, which may relate to the changes of plasma lipoproteins.