[The second phase clinical observation of anti-radiation effect by superoxide dismutase]

Hunan Yi Ke Da Xue Xue Bao. 1998;23(3):308-10.
[Article in Chinese]

Abstract

Multiple center randomized controlled double blind clinical trait was conducted to evaluate the anti-radiotherapy effect by SOD (produced by Hunan Biochemical Work) in 159 patients. Injection of 4000U SOD immediately after receiving radiotherapy significantly reduced the occurrence rate of skin, oral mucosal, pelvic visceral and systematic adverse reaction, only the reduction of leukopenia did not reach the statistical significant level. No adverse effect of SOD injection was observed. The results suggest that SOD is a safe and effective agent to attenuate the radiotherapy reactions.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Double-Blind Method
  • Female
  • Head and Neck Neoplasms / drug therapy
  • Head and Neck Neoplasms / radiotherapy*
  • Humans
  • Male
  • Middle Aged
  • Pelvic Neoplasms / drug therapy
  • Pelvic Neoplasms / radiotherapy*
  • Radiation Injuries / drug therapy*
  • Radiation-Protective Agents / therapeutic use*
  • Radiotherapy, High-Energy
  • Superoxide Dismutase / therapeutic use*
  • Vomiting / drug therapy
  • Vomiting / etiology

Substances

  • Radiation-Protective Agents
  • Superoxide Dismutase