A Surface Antigen Influenza Vaccine. 2. Pyrogenicity and Antigenicity

J Hyg (Lond). 1976 Oct;77(2):173-80. doi: 10.1017/s0022172400024591.


Conventional influenza vaccine containing whole virus particles purified on a zonal centrifuge is pyrogenic and can cause systemic and local adverse side effects. An improved vaccine was therefore prepared which contained only the surface antigens of the virus adsorbed to aluminium hydroxide. The antigenicity of this vaccine was compared with conventional vaccine in chickens. Both vaccines induced similar titres of serum haemagglutination-inhibition and neuraminidase inhibition antibody. The dose response curves, however, were different. The surface antigens at vaccine strength without aluminium hydroxide were of negligible pyrogenicity in rabbits.

MeSH terms

  • Animals
  • Antibodies, Viral / analysis
  • Antigens, Viral*
  • Cell Membrane / immunology*
  • Centrifugation, Zonal
  • Chickens
  • Fever / etiology*
  • Hemagglutination Inhibition Tests
  • Influenza A virus / immunology
  • Influenza Vaccines / administration & dosage
  • Influenza Vaccines / adverse effects
  • Influenza Vaccines / isolation & purification*
  • Neuraminidase / antagonists & inhibitors
  • Neutralization Tests
  • Rabbits


  • Antibodies, Viral
  • Antigens, Viral
  • Influenza Vaccines
  • Neuraminidase