Hypocretin I in the Lateral Hypothalamus Activates Key Feeding-Regulatory Brain Sites

Neuroreport. 2000 Jan 17;11(1):103-8. doi: 10.1097/00001756-200001170-00021.


Hypocretin I (also referred to as orexin A) administered into the lateral hypothalamus (LH) stimulates feeding in rats. We undertook the present study to determine the brain regions activated by LH administration of hypocretin I. Hypocretin I administered into the LH significantly elevated cFos-immunoreactivity in the lateral septal area, the central nucleus of the amygdala, the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, the LH, the posterior and dorsomedial hypothalamus, the perifornical, arcuate and paraventricular nuclei and the nucleus of the solitary tract. These data indicate that LH hypocretin I communicates with other key energy regulatory sites within the hypothalamus, the limbic region and the hindbrain, and suggest that these areas are important in the feeding-stimulatory actions of hypocretin I.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / physiology*
  • Brain Chemistry / drug effects
  • Carrier Proteins*
  • Energy Metabolism / drug effects
  • Feeding Behavior / drug effects*
  • Hypothalamic Area, Lateral / drug effects
  • Hypothalamic Area, Lateral / physiology*
  • Immunohistochemistry
  • Intracellular Signaling Peptides and Proteins*
  • Male
  • Microinjections
  • Neuropeptides*
  • Neurotransmitter Agents / pharmacology*
  • Orexins
  • Proto-Oncogene Proteins c-fos / biosynthesis
  • Rats
  • Rats, Sprague-Dawley
  • Stimulation, Chemical


  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Neurotransmitter Agents
  • Orexins
  • Proto-Oncogene Proteins c-fos