Abstract
Cellular pre-mRNA splicing is inhibited by ICP27, a herpes simplex virus regulatory protein, resulting in the shutoff of host protein synthesis. Here we reveal that ICP27 also mediates the export of some virus RNAs via a Crm1-dependent pathway and present evidence that independent domains are required for these functions. Sorting of some viral mRNAs for nuclear export requires Crm1, while other virus mRNAs are exported via another pathway.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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Biological Transport
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Carrier Proteins / metabolism*
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Chlorocebus aethiops
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Exportin 1 Protein
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Herpesvirus 1, Human / genetics*
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Herpesvirus 1, Human / metabolism
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Humans
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Immediate-Early Proteins / genetics
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Immediate-Early Proteins / metabolism*
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Karyopherins*
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Molecular Sequence Data
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RNA, Messenger / metabolism*
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RNA, Viral / metabolism*
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Receptors, Cytoplasmic and Nuclear*
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Sequence Homology, Amino Acid
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Ultraviolet Rays
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Vero Cells
Substances
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Carrier Proteins
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ICP27 protein, human herpesvirus 1
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Immediate-Early Proteins
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Karyopherins
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RNA, Messenger
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RNA, Viral
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Receptors, Cytoplasmic and Nuclear