A comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: a randomized comparative trial

Hum Reprod. 2000 Mar;15(3):709-12. doi: 10.1093/humrep/15.3.709.

Abstract

A prospective randomized trial was conducted in 148 women to compare the efficacy of two regimens of vaginal misoprostol for termination of second trimester pregnancy. Women aged 16-40 years requesting termination of second trimester pregnancy were randomized into two groups. Women in group 1 were given vaginal misoprostol 400 microg every 3 h for a maximum of five doses in 24 h. Women in group 2 were given vaginal misoprostol 400 microg every 6 h for a maximum of three doses in 24 h. If women did not abort in 24 h, the same regimen was repeated. The median induction-abortion interval in group 1 (15.2 h) was significantly shorter (P < 0.01) than that in the group 2 (19.0 h). The percentage of women who achieved successful abortion within 48 h in group 1 (90.5%) was also significantly higher (P < 0.02) than that in group 2 (75.7%). The incidence of fever was more common in group 1 (P = 0.01). It is concluded that the regimen of vaginal misoprostol 400 microg every 3 h with maximum of five doses in 24 h was more effective than the regimen of misoprostol every 6 h in termination of second trimester pregnancy.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Abortifacient Agents, Nonsteroidal / administration & dosage*
  • Abortifacient Agents, Nonsteroidal / adverse effects*
  • Abortion, Induced / methods*
  • Administration, Intravaginal
  • Adult
  • Female
  • Fever / chemically induced
  • Humans
  • Misoprostol / administration & dosage*
  • Misoprostol / adverse effects*
  • Pregnancy
  • Pregnancy Trimester, Second

Substances

  • Abortifacient Agents, Nonsteroidal
  • Misoprostol