Differential expression patterns of the basic helix-loop-helix transcription factors during aging of the murine brain

Neurosci Lett. 2000 Feb 18;280(2):95-8. doi: 10.1016/s0304-3940(00)00761-8.

Abstract

In this study, we investigated the expression pattern of the basic Helix-Loop-Helix transcription factors during brain aging. We provide the first evidence that NeuroD and ME2 are differentially expressed during brain aging. Modulation of their expression is specific to distinct areas of the aging brain. NeuroD expression is sustained at high levels in aging cerebellum, whereas it severely declines in aging hippocampus. In contrast, the bHLH E-protein ME2 remains expressed in both aged cerebellum and hippocampus, although at lower levels. These observations support the idea that a shift in the transcriptional dynamics controlling gene expression is associated with the progressive functional decline observed during brain aging.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aging*
  • Animals
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Basic Helix-Loop-Helix Transcription Factors
  • Brain / growth & development
  • Brain / metabolism*
  • Cerebellum / growth & development
  • Cerebellum / metabolism
  • Gene Expression Regulation, Developmental
  • Helix-Loop-Helix Motifs / genetics*
  • Hippocampus / growth & development
  • Hippocampus / metabolism
  • In Situ Hybridization
  • Mice
  • Mice, Inbred C57BL
  • Nerve Tissue Proteins / genetics
  • TCF Transcription Factors
  • Time Factors
  • Transcription Factor 4
  • Transcription Factors / genetics*

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Basic Helix-Loop-Helix Transcription Factors
  • Nerve Tissue Proteins
  • TCF Transcription Factors
  • Tcf4 protein, mouse
  • Transcription Factor 4
  • Transcription Factors
  • NeuroD protein