The purpose of this study was to determine the antimicrobial activity of four commercially available cavity disinfectants and one prescription mouthwash as they came into contact with bacteria commonly found in the oral cavity. Streptococcus mutans, salivarius, and Actinomyces viscosus were used in the study. Zones of microbial inhibition were measured in millimeters after 48 hours. The results of this study indicate that all of the antimicrobial agents demonstrated activity against the bacteria tested. Consepsis Solution produced the largest zones of inhibition against all three of the bacteria used.