Fibroblast growth factor-2

Int J Biochem Cell Biol. 2000 Feb;32(2):115-20. doi: 10.1016/s1357-2725(99)00123-5.


Fibroblast growth factor-2 (FGF-2) is a member of a large family of proteins that bind heparin and heparan sulfate and modulate the function of a wide range of cell types. FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis), normal wound healing and tissue development. FGF-2 contains a number of basic residues (pI 9.6) and consists of 12 anti-parallel beta-sheets organized into a trigonal pyrimidal structure. FGF-2 binds to four cell surface receptors expressed as a number of splice variants. Many of the biological activities of FGF-2 have been found to depend on its receptor's intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. However, considerable evidence suggest that intracellular FGF-2 might have a direct biological role particularly within the nucleus. In addition, heparan sulfate proteoglycans have been demonstrated to enhance and inhibit FGF-2 activity. The possibility that FGF-2 activity can be manipulated through alterations in heparan sulfate-binding is currently being exploited in the development of clinical applications aimed at modulating either endogenous or administered FGF-2 activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Fibroblast Growth Factor 2 / chemistry*
  • Fibroblast Growth Factor 2 / pharmacology
  • Fibroblast Growth Factor 2 / physiology*
  • Heparan Sulfate Proteoglycans / metabolism
  • Heparin / metabolism
  • Heparitin Sulfate / metabolism
  • Humans
  • Models, Biological
  • Models, Molecular
  • Protein Conformation
  • Signal Transduction


  • Heparan Sulfate Proteoglycans
  • Fibroblast Growth Factor 2
  • Heparin
  • Heparitin Sulfate