Bi-directional signal transduction by integrin receptors

Int J Biochem Cell Biol. 2000 Feb;32(2):171-88. doi: 10.1016/s1357-2725(99)00043-6.


The integrin family of cell surface glycoproteins functions primarily as receptors for extracellular matrix ligands. There are now many well characterized integrin-ligand interactions which are known to influence many aspects of cell behaviour including cell morphology, cell adhesion, cell migration as well as cellular proliferation and differentiation. However, in fulfilling these functions, integrins are not simple adhesion receptors that physically mediate connections across the plasma membrane. Rather, integrin function itself is highly regulated, largely through the formation of specific associations with both structural and regulatory components within cells. It is these intracellular interactions which allow integrin function to effect many biochemical signalling pathways and therefore to impinge upon complex cellular activities. Recently, much research has focused on elucidating the molecular mechanisms which control integrin function and the molecular processes which transduce integrin-mediated signalling events. In this review, we discuss progress in the field of integrin signal transduction including, where applicable, potential therapeutic applications arising from the research.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium-Binding Proteins / physiology
  • Calreticulin
  • Carrier Proteins / physiology
  • Cell Adhesion / physiology
  • Cell Adhesion Molecules / physiology
  • Cell Membrane / physiology
  • Extracellular Matrix / physiology
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Humans
  • Integrins / physiology*
  • Mitogen-Activated Protein Kinases / physiology
  • Protein Serine-Threonine Kinases / physiology
  • Protein-Tyrosine Kinases / physiology
  • Ribonucleoproteins / physiology
  • Signal Transduction / physiology*


  • CIB1 protein, human
  • Calcium-Binding Proteins
  • Calreticulin
  • Carrier Proteins
  • Cell Adhesion Molecules
  • Integrins
  • Ribonucleoproteins
  • integrin-linked kinase
  • Protein-Tyrosine Kinases
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • PTK2 protein, human
  • Protein Serine-Threonine Kinases
  • Mitogen-Activated Protein Kinases