Biologic functions of the IFN-gamma receptors

Allergy. 1999 Dec;54(12):1233-51. doi: 10.1034/j.1398-9995.1999.00099.x.


Interferon-gamma (IFN-gamma) is a cytokine that plays an important role in inducing and modulating an array of immune responses. Cellular responses to IFN-gamma are mediated by its heterodimeric cell-surface receptor (IFN-gammaR), which activates downstream signal transduction cascades, ultimately leading to the regulation of gene expression. In order to study the role of IFN-gamma in a number of immune responses and pathways, researchers have generated mice with altered patterns of IFN-gammaR gene expression. These studies, together with analyses of naturally occurring mutations of the IFN-gammaR in man, have been instrumental in elucidating the diverse functions of IFN-gamma, and are the subject of this review.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression
  • Humans
  • Immunity, Cellular
  • Interferon gamma Receptor
  • Mice
  • Receptors, Interferon / genetics
  • Receptors, Interferon / physiology*
  • Signal Transduction


  • Receptors, Interferon