In vitro senescence models for human T lymphocytes

Vaccine. 2000 Feb 25;18(16):1666-74. doi: 10.1016/s0264-410x(99)00504-6.


Immunosenescence is an age-associated dysregulation of immune function which may contribute to the increased susceptibility of the elderly to infectious disease. Although age-associated changes are measurable in the innate immune system, it is the adaptive arm of the immune system which is particularly susceptible to the deleterious effects of ageing, especially the T cell compartment. In this review, the characteristics of longitudinal ageing in cultured monoclonal human T cell populations will be summarized. It will be argued that parallels between this in vitro model and T cell senescence in vivo suggest the use of such models to screen for interventions ameliorating immunosenescence in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / immunology
  • Antigens, CD / metabolism
  • Apoptosis
  • Biomarkers / analysis
  • Cell Division
  • Cellular Senescence / immunology*
  • Clone Cells
  • Cytokines / metabolism
  • Humans
  • In Vitro Techniques
  • Mitosis
  • Models, Biological*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / enzymology
  • T-Lymphocytes / immunology*
  • Telomerase / metabolism


  • Antigens, CD
  • Biomarkers
  • Cytokines
  • Telomerase