MSY2: A Slowly Evolving Minisatellite on the Human Y Chromosome Which Provides a Useful Polymorphic Marker in Chinese Populations

Gene. 2000 Feb 22;244(1-2):29-33. doi: 10.1016/s0378-1119(00)00021-4.

Abstract

We present the second human Y-specific minisatellite, MSY2 (DYS440). It consists of three or four copies of a 99-110bp repeat unit and is located about 1kb upstream of the DBY gene. The most common allele contains four units, but a three-unit allele has arisen on at least four occasions; in chimpanzees and orangutans, MSY2 contains only two units. It is therefore evolving slowly and provides a particularly useful polymorphic marker for Chinese populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Base Sequence
  • Cell Line
  • China
  • DNA / chemistry
  • DNA / genetics
  • DNA Probes
  • Female
  • Genetic Markers
  • Genetic Variation
  • Humans
  • Male
  • Minisatellite Repeats / genetics*
  • Molecular Sequence Data
  • Pan troglodytes / genetics
  • Polymorphism, Genetic
  • Pongo pygmaeus / genetics
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid
  • Y Chromosome / genetics*

Substances

  • DNA Probes
  • Genetic Markers
  • DNA

Associated data

  • GENBANK/AF207845
  • GENBANK/AF207846