Antigen processing and presentation by intestinal epithelial cells - polarity and complexity

Immunol Today. 2000 Mar;21(3):123-8. doi: 10.1016/s0167-5699(99)01575-3.


The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg and colleagues discuss the evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Cell Polarity
  • Epithelial Cells / cytology
  • Epithelial Cells / immunology
  • Histocompatibility Antigens Class II / metabolism
  • Humans
  • Intestinal Mucosa / cytology*
  • Intestinal Mucosa / immunology*
  • Models, Biological


  • Histocompatibility Antigens Class II