Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

F Aloisi; F Ria; L Adorini

doi:10.1016/s0167-5699(99)01512-1

Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

Immunol Today. 2000 Mar;21(3):141-7. doi: 10.1016/s0167-5699(99)01512-1.

Authors

F Aloisi¹, F Ria, L Adorini

Affiliation

¹ The Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

PMID: 10689302
DOI: 10.1016/s0167-5699(99)01512-1

Abstract

Analysis of the mechanisms underlying CNS immune surveillance and immunopathology have provided new insights into the intracerebral regulation of immune responses. Here, Francesca Aloisi, Francesco Ria and Luciano Adorini review the role of CNS antigen presenting cells and focus on the control of Th1 and Th2 responses by microglia and astrocytes.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antigen-Presenting Cells / immunology*
Astrocytes / immunology*
Central Nervous System / immunology
Humans
Microglia / immunology*
Models, Biological
Neuroimmunomodulation
T-Lymphocytes / immunology*