Tyrosine kinase SYK: essential functions for immunoreceptor signalling

Immunol Today. 2000 Mar;21(3):148-54. doi: 10.1016/s0167-5699(99)01574-1.


The tyrosine kinase SYK plays critical roles in signalling through immune receptors. Gene-targeting studies have identified the cell types that require SYK for development and function, and the receptors that use SYK as well as their downstream signalling effectors. There is also evidence of a role for SYK in non-immune cells and in the maintenance of vascular integrity.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • Blood Platelets / immunology
  • Enzyme Precursors / immunology*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Killer Cells, Natural / immunology
  • Protein-Tyrosine Kinases / immunology*
  • Receptors, Fc / metabolism
  • Receptors, Immunologic / metabolism*
  • Signal Transduction
  • Syk Kinase
  • T-Lymphocyte Subsets / immunology
  • ZAP-70 Protein-Tyrosine Kinase


  • Enzyme Precursors
  • Intracellular Signaling Peptides and Proteins
  • Receptors, Fc
  • Receptors, Immunologic
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase
  • ZAP-70 Protein-Tyrosine Kinase
  • ZAP70 protein, human