Molecules of the brain

Hosp Pract (1995). 2000 Feb 15;35(2):41-8, 51-4. doi: 10.3810/hp.2000.02.186.

Abstract

Progress against a range of brain disorders is being sustained by the use of genetic research techniques to identify specific molecules involved in brain disease, and by the realization that the identified molecules may disclose novel therapeutic targets. Both strategies are illustrated by recent insights and interventions in Alzheimer's disease and Parkinson's disease.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism*
  • Amyloid beta-Protein Precursor / genetics
  • Brain Chemistry / genetics*
  • Brain Chemistry / physiology*
  • Genetics, Medical*
  • Humans
  • Membrane Proteins / genetics
  • Molecular Biology*
  • Mutation / genetics
  • Nerve Tissue Proteins / genetics
  • Parkinson Disease / drug therapy
  • Parkinson Disease / genetics*
  • Parkinson Disease / metabolism*
  • Pharmacogenetics
  • Presenilin-1
  • Receptors, Cholinergic / drug effects
  • Receptors, Cholinergic / genetics
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / genetics
  • Receptors, Glutamate / drug effects
  • Receptors, Glutamate / genetics
  • Synucleins

Substances

  • Amyloid beta-Protein Precursor
  • Membrane Proteins
  • Nerve Tissue Proteins
  • PSEN1 protein, human
  • Presenilin-1
  • Receptors, Cholinergic
  • Receptors, Dopamine
  • Receptors, Glutamate
  • Synucleins