Effects of CpG DNA on Th1/Th2 balance in asthma

Curr Top Microbiol Immunol. 2000;247:211-25. doi: 10.1007/978-3-642-59672-8_15.

Abstract

Thus, in our studies, we demonstrated that CpG ODN are effective in preventing the development of eosinophilic airway inflammation and bronchial hyper-reactivity in a murine model of asthma. Antigen-associated elevation of serum IgE levels is also suppressed. CpG ODN, administered in conjunction with antigen, is also effective in down-regulation of established Th2 responses. This protection is neither murine strain-dependent nor model-dependent. Although these effects of CpG ODN are associated with the induction of the Th1 cytokines IFN-gamma and IL-12, neither cytokine is absolutely required for the protection. These results suggest that CpG ODN may be an effective immunomodulatory agent in the treatment, and possibly prevention, of asthma.

Publication types

  • Review

MeSH terms

  • Animals
  • Asthma / immunology*
  • Asthma / prevention & control
  • Asthma / therapy
  • CpG Islands / immunology*
  • DNA / immunology*
  • Humans
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*

Substances

  • DNA