A classical setting for associations between markers and loci affecting quantitative traits

Genet Res. 1999 Dec;74(3):271-7. doi: 10.1017/s0016672399004231.

Abstract

We examine the relationships between a genetic marker and a locus affecting a quantitative trait by decomposing the genetic effects of the marker locus into additive and dominance effects under a classical genetic model. We discuss the structure of the associations between the marker and the trait locus, paying attention to non-random union of gametes, multiple alleles at the marker and trait loci, and non-additivity of allelic effects at the trait locus. We consider that this greater-than-usual level of generality leads to additional insights, in a way reminiscent of Cockerham's decomposition of genetic variance into five terms: three terms in addition to the usual additive and dominance terms. Using our framework, we examine several common tests of association between a marker and a trait.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Genetic Markers
  • Humans
  • Mathematical Computing
  • Models, Genetic*
  • Quantitative Trait, Heritable*

Substances

  • Genetic Markers