Ribosome synthesis in Saccharomyces cerevisiae

Annu Rev Genet. 1999;33:261-311. doi: 10.1146/annurev.genet.33.1.261.

Abstract

The synthesis of ribosomes is one of the major metabolic pathways in all cells. In addition to around 75 individual ribosomal proteins and 4 ribosomal RNAs, synthesis of a functional eukaryotic ribosome requires a remarkable number of trans-acting factors. Here, we will discuss the recent, and often surprising, advances in our understanding of ribosome synthesis in the yeast Saccharomyces cerevisiae. These will underscore the unexpected complexity of eukaryotic ribosome synthesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • RNA, Fungal / genetics
  • RNA, Fungal / metabolism
  • RNA, Ribosomal / genetics
  • RNA, Ribosomal / metabolism
  • Ribosomal Proteins / genetics
  • Ribosomal Proteins / metabolism
  • Ribosomes / genetics
  • Ribosomes / physiology*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*

Substances

  • Fungal Proteins
  • RNA, Fungal
  • RNA, Ribosomal
  • Ribosomal Proteins