Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula

J Nat Prod. 2000 Feb;63(2):279-82. doi: 10.1021/np990353f.

Abstract

A collection of Lyngbya majuscula from Palau contained the peptides dolastatin 3 (1), homodolastatin 3 (2), and kororamide (3), together with aplysiatoxin (4), debromoaplysiatoxin (5), and oscillatoxin A (6). The structures of the new peptides homodolastatin 3 (2) and kororamide (3) were determined by interpretation of spectroscopic data and chemical degradation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / analysis
  • Depsipeptides*
  • Gas Chromatography-Mass Spectrometry
  • HIV Integrase Inhibitors / chemistry
  • HIV Integrase Inhibitors / isolation & purification*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Conformation
  • Palau
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • Amino Acids
  • Depsipeptides
  • HIV Integrase Inhibitors
  • Peptides, Cyclic
  • dolastatin 3
  • homodolastatin 3
  • kororamide