Heat mutagenesis in bacteriophage T4: the transversion pathway

Proc Natl Acad Sci U S A. 1976 Nov;73(11):4159-63. doi: 10.1073/pnas.73.11.4159.


Heat induces transversions (as well as transitions) at G-C base pairs in bacteriophage T4. The target base for transversions is guanine,which is converted to a product which is sometimes replicated and transcribed as a pyrimidine.A model for this process is proposed in which the deoxyguanosine glycosidic bond migrates from N9 to N2: the resulting deoxyneoguanosine may pair with normal guanine to produce G-C leads to C-G transversions.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Coliphages*
  • Guanine Nucleotides
  • Hot Temperature*
  • Hydrogen Bonding
  • Kinetics
  • Mutation*


  • Guanine Nucleotides