SAP family proteins

Biochem Biophys Res Commun. 2000 Mar 5;269(1):1-6. doi: 10.1006/bbrc.1999.1893.


Thus far, five members including Dlg, SAP97/hDlg, SAP90/PSD-95, SAP102, and PSD-93/chapsyn110 which belong to SAP family have been identified. Recent studies have revealed that these proteins play important roles in the localization and function of glutamate receptors and K(+) channels. Although most of them have been reported to be localized to the synapse, only one member, SAP97, is expressed also in the epithelial cells. In this review, we have summarized structural characters of SAP family proteins and discuss their functions in neurons and epithelial cells.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Motifs
  • Animals
  • Discs Large Homolog 1 Protein
  • Epithelial Cells / metabolism
  • Humans
  • Membrane Proteins
  • Nerve Tissue Proteins / chemistry*
  • Nerve Tissue Proteins / metabolism*
  • Potassium Channels / metabolism
  • Receptors, Glutamate / metabolism
  • Receptors, Kainic Acid / metabolism
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Synapses / metabolism


  • Adaptor Proteins, Signal Transducing
  • DLG1 protein, human
  • Discs Large Homolog 1 Protein
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Potassium Channels
  • Receptors, Glutamate
  • Receptors, Kainic Acid
  • Receptors, N-Methyl-D-Aspartate