Effects of a low-glycaemic index spaghetti meal on glucose tolerance and lipaemia at a subsequent meal in healthy subjects

Eur J Clin Nutr. 2000 Jan;54(1):24-8. doi: 10.1038/sj.ejcn.1600887.


Objective: The aim of the study was to evaluate the impact of a low glycaemic index (GI) breakfast on glucose tolerance and lipaemia at a subsequent lunch meal.

Design: A low GI spaghetti meal and a high-GI white wheat bread (WWB) reference meal were served in the morning after an overnight fast in random order. Four hours after the breakfast, the subjects were given a second meal-a standardized high-GI lunch-and the blood glucose, insulin and lipid responses were measured after the lunch meal.

Setting: The study was performed at the Department of Applied Nutrition and Food Chemistry, Lund University, Sweden.

Subjects: Ten healthy volunteers, eight women and two men, aged 25-51 y, with normal body mass indices, were recruited.

Results: Lowered glucose and insulin responses and reduced serum triglyceride (TG) level were found at the subsequent lunch meal when the low-GI spaghetti meal was given as a breakfast. No differences in total serum cholesterol or HDL cholesterol were seen after lunch, when preceded by the WWB reference breakfast or the spaghetti breakfast, respectively.

Conclusions: Improved glucose tolerance and lowered serum TG levels can appear in the course of a single day. As insulin resistance and raised postprandial TG concentration are known risk factors for cardiovascular disease, the present study adds evidence for a beneficial role of a low-GI diet.

Sponsorship: Cerealia Foundation for Research and Development (project no. 232) and the Swedish Council for Forestry and Agricultural Research. European Journal of Clinical Nutrition (2000) 54, 24-28

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Blood Glucose / drug effects*
  • Blood Glucose / metabolism
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Diet*
  • Dietary Carbohydrates / administration & dosage
  • Dietary Carbohydrates / pharmacology*
  • Enzyme-Linked Immunosorbent Assay
  • Fasting / blood
  • Female
  • Humans
  • Insulin / blood*
  • Male
  • Middle Aged
  • Triglycerides / blood*


  • Blood Glucose
  • Cholesterol, HDL
  • Dietary Carbohydrates
  • Insulin
  • Triglycerides
  • Cholesterol