GERD progressing to diffuse esophageal spasm and then to achalasia

Dig Dis Sci. 2000 Jan;45(1):110-3. doi: 10.1023/a:1005469629067.


The pathophysiology of achalasia is not completely understood. Several reports have suggested that esophageal motility disorders may progress from one type to another. We report a patient with symptoms and esophageal motility findings consistent with gastroesophageal reflux who subsequently developed a diffuse esophageal spasm and then achalasia. We believe this to be the first report showing such a progression in esophageal motility.

MeSH terms

  • Adult
  • Esophageal Achalasia / etiology*
  • Esophageal Achalasia / physiopathology
  • Esophageal Spasm, Diffuse / etiology*
  • Esophageal Spasm, Diffuse / physiopathology
  • Esophagogastric Junction / physiopathology
  • Esophagus / physiopathology
  • Gastroesophageal Reflux / complications*
  • Humans
  • Manometry