Suppressor cells in demyelinating disease: a new paradigm for the new millennium

J Neuroimmunol. 1999 Dec;100(1-2):53-7. doi: 10.1016/s0165-5728(99)00208-8.


This brief review highlights investigations conducted over the past three decades concerning the role of suppressor T cells in the regulation of experimental autoimmune encephalomyelitis (EAE). In addition, more recent studies are summarized which suggest that apoptosis of autoreactive T cells is also involved in the regulation of EAE. The possibility that natural killer (NK) cells mediate apoptosis is also considered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology
  • Encephalomyelitis, Autoimmune, Experimental / immunology*
  • Humans
  • Killer Cells, Natural / immunology
  • Multiple Sclerosis / immunology
  • Rats
  • Rats, Inbred Lew
  • T-Lymphocytes, Regulatory / immunology*
  • Time Factors