Potential mechanisms of interleukin-1 involvement in cerebral ischaemia

J Neuroimmunol. 1999 Dec;100(1-2):203-15. doi: 10.1016/s0165-5728(99)00202-7.


Interleukin-1 (IL-1) has pleiotropic actions in the central nervous system. During the last decade, a growing corpus of evidence has indicated an important role of this cytokine in the development of brain damage following cerebral ischaemia. The expression of IL-1 in the brain is dramatically increased during the early and chronic stage of infarction. The most direct evidence that IL-1 contributes significantly to ischaemic injury is that (1) central administration of IL-1beta exacerbates brain damage, and (2) injection or over-expression of interleukin-1 receptor antagonist, and blockade of interleukin-1beta converting enzyme activity reduce, dramatically, infarction and improve behavioural deficit. The mechanisms underlying IL-1 actions in stroke are not definitively elucidated, and it seems likely that its effects are mediated through stimulation and inhibition of wide range of pathophysiological processes.

Publication types

  • Review

MeSH terms

  • Brain Injuries / etiology
  • Brain Injuries / metabolism
  • Brain Injuries / therapy
  • Brain Ischemia / complications
  • Brain Ischemia / metabolism*
  • Humans
  • Inflammation / metabolism
  • Interleukin-1 / biosynthesis*
  • Interleukin-1 / physiology*
  • Models, Biological
  • Temperature


  • Interleukin-1