Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects

Eye (Lond). 1999 Oct;13 ( Pt 5):656-9. doi: 10.1038/eye.1999.178.

Abstract

Purpose: To evaluate aqueous humour levels of topical 0.3% ciprofloxacin and 0.3% ofloxacin in the same subjects.

Methods: Thirty-two bilateral cataractous patients received topical 0.3% ciprofloxacin in one eye and 0.3% ofloxacin in the other eye before each cataract extraction. Eyedrops were repetitively instilled for 6 h. Aqueous humour samples were collected and assayed for drug concentrations by a method described originally by us using high-performance liquid chromatography.

Results: Mean aqueous ciprofloxacin and ofloxacin levels were 0.33 +/- 0.04 microgram/ml (mean +/- SEM) and 1.34 +/- 0.14 micrograms/ml respectively (p < 0.0001).

Conclusion: Ofloxacin level in the aqueous humour is 4 times higher than that of ciprofloxacin in the same subjects.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Anti-Infective Agents / pharmacokinetics*
  • Antibiotic Prophylaxis / methods
  • Aqueous Humor / metabolism*
  • Cataract Extraction*
  • Chromatography, High Pressure Liquid
  • Ciprofloxacin / pharmacokinetics*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Ofloxacin / pharmacokinetics*
  • Ophthalmic Solutions

Substances

  • Anti-Infective Agents
  • Ophthalmic Solutions
  • Ciprofloxacin
  • Ofloxacin