Toxicity of Passiflora incarnata L

J Toxicol Clin Toxicol. 2000;38(1):63-6. doi: 10.1081/clt-100100919.


Background: Herbal medicines may have significant adverse effects which are not suspected or recognized.

Case report: A 34-year-old female developed severe nausea, vomiting, drowsiness, prolonged QTc, and episodes of nonsustained ventricular tachycardia following self-administration of a herbal remedy, Passiflora incarnata L., at therapeutic doses. The possible association of symptoms with passiflora was not recognized for several days. She required hospital admission for cardiac monitoring and intravenous fluid therapy.

Conclusions: Passiflora incarnata was associated with significant adverse effects in this patient. It is important to ask specifically about the use of herbal medicines in patients with undiagnosed illnesses.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Electrocardiography / drug effects
  • Female
  • Harmine / adverse effects
  • Harmine / analogs & derivatives
  • Humans
  • Nausea / chemically induced
  • Plants, Medicinal / adverse effects*
  • Tachycardia, Ventricular / chemically induced
  • Vomiting / chemically induced


  • Harmine
  • harman