Rapid Loss of Superoxide Dismutase Activity During Antigen-Induced Asthmatic Response

Lancet. 2000 Feb 19;355(9204):624. doi: 10.1016/S0140-6736(99)04736-4.

Abstract

Loss of superoxide dismutase activity occurs within minutes of an acute asthmatic response to segmental antigen instillation into the lung of individuals with atopic asthma. Decreased activity undoubtedly contributes to airway inflammation and injury through increased formation of reactive oxygen and nitrogen species, and suggests that enrichment of lung antioxidants is therapeutic for asthma.

Publication types

  • Letter
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Allergens
  • Antioxidants / metabolism*
  • Asthma / diagnosis
  • Asthma / immunology
  • Asthma / metabolism*
  • Bronchial Provocation Tests
  • Case-Control Studies
  • Female
  • Free Radical Scavengers / metabolism*
  • Humans
  • Lung / metabolism*
  • Male
  • Superoxide Dismutase / metabolism*
  • Time Factors

Substances

  • Allergens
  • Antioxidants
  • Free Radical Scavengers
  • Superoxide Dismutase