A Phase I Study of Intralesional Administration of an Adenovirus Vector Expressing the HSV-1 Thymidine Kinase Gene (AdV.RSV-TK) in Combination With Escalating Doses of Ganciclovir in Patients With Cutaneous Metastatic Malignant Melanoma

Hum Gene Ther. 2000 Feb 10;11(3):487-503. doi: 10.1089/10430340050015950.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I

MeSH terms

  • Adenoviridae / genetics*
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • Female
  • Ganciclovir / administration & dosage
  • Ganciclovir / therapeutic use*
  • Genetic Therapy*
  • Genetic Vectors
  • Herpesvirus 1, Human / enzymology
  • Herpesvirus 1, Human / genetics*
  • Humans
  • Male
  • Melanoma / therapy*
  • Skin Neoplasms / therapy*
  • Thymidine Kinase / genetics*

Substances

  • Antiviral Agents
  • Thymidine Kinase
  • Ganciclovir