Persistent wound infection after herniotomy associated with small-colony variants of Staphylococcus aureus

Infection. 2000 Jan-Feb;28(1):53-4. doi: 10.1007/s150100050014.


A small-colony variant (SCV) of Staphylococcus aureus was cultured from a patient with a persistent wound infection (abscess and fistula) 13 months after herniotomy. The strain was nonhemolytic, nonpigmented and grew only anaerobically on Schaedler agar. As it was coagulase-negative, it was initially misidentified as a coagulase-negative Staphylococcus. In further analysis, however, the microorganism was shown to be an auxotroph that reverted to normal growth and morphology in the presence of menadione and hemin (Schaedler agar) and could be identified as a SCV of Staphylococcus aureus. Surgery and antibiotic treatment of the patient with flucloxacillin and rifampicin for 4 weeks resulted in healing of the chronic wound infection.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Abscess / drug therapy
  • Abdominal Abscess / microbiology
  • Antibiotics, Antitubercular / therapeutic use
  • Fistula / drug therapy
  • Fistula / microbiology
  • Floxacillin / therapeutic use
  • Herniorrhaphy*
  • Humans
  • Male
  • Middle Aged
  • Penicillins / therapeutic use
  • Rifampin / therapeutic use
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / isolation & purification
  • Surgical Wound Infection / drug therapy
  • Surgical Wound Infection / microbiology*


  • Antibiotics, Antitubercular
  • Penicillins
  • Floxacillin
  • Rifampin