Melanin-concentrating hormone (MCH) modifies memory retention in rats

Peptides. 1999 Dec;20(12):1517-9. doi: 10.1016/s0196-9781(99)00164-3.

Abstract

The purpose of the present study was to evaluate the possible effect of melanin-concentrating hormone (MCH) on learning and memory by using the one-trial step-down inhibitory avoidance test in rats. The peptide was infused into hippocampus, amygdala, and entorhinal cortex. MCH caused retrograde facilitation when given at 0 or 4 h post-training into hippocampus, but only at 0 h into amygdala. From these results, it seems that MCH modulates memory early after training by acting on both the amygdala and hippocampus and, 4 h after training, on the hippocampus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amygdala / drug effects
  • Amygdala / physiology
  • Animals
  • Avoidance Learning / drug effects
  • Avoidance Learning / physiology
  • Entorhinal Cortex / drug effects
  • Entorhinal Cortex / physiology
  • Hippocampus / drug effects
  • Hippocampus / physiology
  • Hypothalamic Hormones / administration & dosage
  • Hypothalamic Hormones / pharmacology*
  • Male
  • Melanins / administration & dosage
  • Melanins / pharmacology*
  • Memory / drug effects*
  • Memory / physiology
  • Pituitary Hormones / administration & dosage
  • Pituitary Hormones / pharmacology*
  • Rats
  • Rats, Wistar
  • Time Factors

Substances

  • Hypothalamic Hormones
  • Melanins
  • Pituitary Hormones
  • melanin-concentrating hormone