Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide

Psychiatry Res. 2000 Feb 14;93(1):73-8. doi: 10.1016/s0165-1781(00)00128-1.

Abstract

Genotype frequencies of functional polymorphisms in the genes encoding the serotonin transporter (5-HTT) and the enzyme catechol-O-methyltransferase (COMT) were not different in 51 suicidal inpatients compared to 51 control subjects. Within the patient group, increased hopelessness and suicide ideation were associated with homozygosity of the 5-HTT high promotor activity allele.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Carrier Proteins / genetics*
  • Case-Control Studies
  • Catechol O-Methyltransferase / genetics*
  • Chi-Square Distribution
  • Depressive Disorder, Major / genetics*
  • Depressive Disorder, Major / psychology*
  • Female
  • Genotype
  • Homozygote*
  • Humans
  • Male
  • Membrane Glycoproteins / genetics*
  • Membrane Transport Proteins*
  • Mental Disorders / genetics
  • Mental Disorders / psychology
  • Middle Aged
  • Nerve Tissue Proteins*
  • Polymorphism, Genetic
  • Psychiatric Status Rating Scales
  • Risk Factors
  • Serotonin / genetics*
  • Serotonin Plasma Membrane Transport Proteins
  • Suicide / prevention & control*

Substances

  • Carrier Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Catechol O-Methyltransferase