Palmoplantar hyperkeratosis in Irish terriers: evidence of autosomal recessive inheritance

J Small Anim Pract. 2000 Feb;41(2):52-5. doi: 10.1111/j.1748-5827.2000.tb03162.x.


An abnormal development of the epidermis of the footpad was observed in Irish terriers. At the age of six months, the affected animals developed smooth parchment-like footpads. The pad epidermis then hardened and grew lateral cone-like protrusions of up to 5 mm in diameter. Fissures and cracks developed and these predisposed the animal to secondary infection. The repeated occurrence in subsequent generations led to the assumption of a hereditary form of hyperkeratosis. Evidence for an autosomal recessive mode of inheritance was derived from a retrospective analysis of the breeder's records. The clinical, histopathological and ultrastructural features of the disease are presented and the genetic transmission and its implications discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Aberrations
  • Chromosome Disorders
  • Dog Diseases / genetics*
  • Dog Diseases / pathology
  • Dogs
  • Female
  • Foot / pathology
  • Keratoderma, Palmoplantar / genetics
  • Keratoderma, Palmoplantar / pathology
  • Keratoderma, Palmoplantar / veterinary*
  • Male
  • Pedigree