The effects of mechanical forces on lung functions

Respir Physiol. 2000 Jan;119(1):1-17. doi: 10.1016/s0034-5687(99)00092-4.


The lung is a dynamic organ that is subjected to mechanical forces throughout development and adult life. This review article addresses the types of mechanical forces in the lung and their effects on development and normal lung functions. The effects of mechanical forces on the various different cell types of the lung are discussed, as are the mechanisms underlying mechanotransduction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Embryonic and Fetal Development
  • Lung / cytology
  • Lung / embryology
  • Lung / growth & development
  • Lung / physiology*
  • Respiratory Mechanics / physiology*
  • Signal Transduction / physiology